Perispinal Etanercept RCT 2019
Gold Coast, Australia (January 3, 2020): The results of a randomized, placebo-controlled, double-blind clinical trial of perispinal etanercept were published today, confirming the efficacy and remarkable results of perispinal etanercept in a cohort of stroke survivors with relentless, intractable daily pain after stroke. The individuals were treated an average of about 4 years after stroke and each reported constant daily pain after their stroke that had failed to adequately respond to all previous forms of treatment. They received two doses of perispinal etanercept, each two weeks apart, with the control group receiving two doses of saline administered perispinally. The control group had no change in their daily pain, but the etanercept group had a significant reduction in pain, measured at 30 days, with 30% of the etanercept patients showing near complete pain abatement after the first etanercept treatment. The study concludes: “Perispinal etanercept can provide significant and ongoing benefits for the chronic post-stroke management of pain and greater shoulder flexion by the paretic arm. Effects are rapid and highly significant, supporting direct action on brain function.”
The clinical trial results published on January 3, 2020 in the journal Expert Opinion on Investigational Drugs. Learn More.
Posted by Webmaster on Sunday, January 5, 2020 at 12:39 pm
Filed under Blog Posts, Brain Research, INR News, Uncategorized · Tagged with central post-stroke pain, Chronic Post-Stroke Pain, CPSP, Edward Tobinick MD, Institute of Neurological Recovery, Neuroinflammation, Perispinal Etanercept, Stroke, Stroke Recovery, TNF, Tobinick
Immediate neurological recovery after treatment at the INR Boca Raton, August 13, 2018
Immediate neurological recovery after treatment at the INR Boca Raton, August 13, 2018, two years after a brainstem stroke. Improvements noted in chronic post-stroke pain, visual tracking and gait within minutes after treatment.
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Disclaimer: Individual results vary, not all patients respond. Additional doses may be necessary to maintain the clinical response. Treatment is innovative (“off-label”). Terms of Use
Posted by INR PLLC on Friday, August 17, 2018 at 5:08 pm
Filed under Blog Posts, Brain Research, INR News, Uncategorized · Tagged with Anti-Inflammatory, Boca Raton, Chronic pain, Etanercept, Florida, Inflammation, Institute of Neurological Recovery, Perispinal, Recovery, Rehabilitation, Stroke, Therapeutic, TNF, Tobinick, treatment, tumor necrosis factor, Vision, Walking
Rapid Improvement in Walking, Balance, Tone & Cognition 3 Years After Stroke
From Kentucky to the INR in Boca Raton, Florida. Published July 16, 2018.
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Disclaimer: Individual results vary, not all patients respond. Additional doses may be necessary to maintain the clinical response. Treatment is innovative (“off-label”). Terms of Use
Posted by INR PLLC on Monday, July 16, 2018 at 2:15 pm
Filed under Blog Posts, Brain Research, INR News, Uncategorized · Tagged with Anti-Inflammatory, antiinflammatory, Boca Raton, Cognition, Dr. Tobinick, Edward Tobinick MD, Etanercept, Fatigue, Florida, Gait, Inflammation, INR, INR PLLC, Institute of Neurological Recovery, Pain, Perispinal Etanercept, Post Stroke, Post Stroke Pain, PostStroke, PSE, Shoulder Pain, spasticity, Stroke, Stroke Recovery, Stroke Rehabilitation, Stroke Treatment, TNF, TNFa, Tobinick, Tumor Necrosis Factor Alpha, Walking
From Glascow, Scotland, 1 week after treatment at the INR in Boca Raton, Florida, filmed in March 2018. Discussion with Edward Tobinick MD. Treatment was performed 8 years after stroke that caused intractable aphasia, hearing and sensory dysfunction and difficulty using the right hand (motor dysfunction) prior to treatment. A graphic illustration suggesting that chronic neuroinflammation, mediated by excess TNF in the brain, can reversibly inactivate brain circuits necessary for optimal brain function and connectivity.
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Disclaimer: Individual results vary, not all patients respond. Additional doses may be necessary to maintain the clinical response. Treatment is innovative (“off-label”). Terms of Use
Posted by INR PLLC on Tuesday, May 15, 2018 at 12:38 pm
Filed under Blog Posts, Brain Research, INR News, Uncategorized · Tagged with Aphasia, Hearing, Post Stroke, PostStroke, Sensation, Stroke, Stroke Recovery, Stroke Rehabilitation, Stroke Treatment
Walking without a stick (cane) after treatment at the INR! Eddie and his family from Scotland, visiting the INR Boca Raton, on April 23, 2018.
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Disclaimer: Individual results vary, not all patients respond. Additional doses may be necessary to maintain the clinical response. Treatment is innovative (“off-label”). Terms of Use
Posted by INR PLLC on Tuesday, April 24, 2018 at 1:57 pm
Filed under Blog Posts, Brain Research, INR News, Uncategorized · Tagged with Anti-Inflammatory, antiinflammatory, Balance, Boca Raton, Cognition, Dr. Tobinick, Edward Tobinick MD, Etanercept, Florida, Inflammation, INR, INR PLLC, Institute of Neurological Recovery, Perispinal Etanercept, Post Stroke, PostStroke, PSE, Scotland, spasticity, Speech, Stroke, Stroke Recovery, Stroke Rehabilitation, Stroke Treatment, TNF, TNFa, Tobinick, Tumor Necrosis Factor Alpha, Walking
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Disclaimer: Individual results vary, not all patients respond. Additional doses may be necessary to maintain the clinical response. Treatment is innovative (“off-label”). Terms of Use
Posted by INR PLLC on Friday, April 13, 2018 at 5:59 pm
Filed under Blog Posts, Brain Research, INR News, Uncategorized · Tagged with Anti-Inflammatory, antiinflammatory, Boca Raton, Dr. Tobinick, Edward Tobinick MD, Etanercept, Florida, Inflammation, INR, INR PLLC, Institute of Neurological Recovery, Perispinal Etanercept, Post Stroke, PostStroke, PSE, Stroke, Stroke Recovery, Stroke Rehabilitation, Stroke Treatment, TNF, TNFa, Tobinick, Tumor Necrosis Factor Alpha, Vision
Patient and father, from Iceland, discusses improvements 2 years after stroke. The stroke happened at age 17. Improvements discussed include: spasticity, left neglect, walking, speech, fatigue, and improved ability to swallow.
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Disclaimer: Individual results vary, not all patients respond. Additional doses may be necessary to maintain the clinical response. Treatment is innovative (“off-label”). Terms of Use
Posted by INR PLLC on Friday, March 9, 2018 at 5:24 pm
Filed under Blog Posts, Brain Research, INR News, Uncategorized · Tagged with Anti-Inflammatory, antiinflammatory, Aphasia, Boca Raton, Cognition, Dr. Tobinick, Edward Tobinick MD, Etanercept, Fatigue, Florida, Gait, Inflammation, INR, INR PLLC, Institute of Neurological Recovery, Left Neglect, Perispinal Etanercept, Post Stroke, PostStroke, PSE, spasticity, Stroke, Stroke Recovery, Stroke Rehabilitation, Stroke Treatment, Swallowing, TNF, TNFa, Tobinick, Tumor Necrosis Factor Alpha, Walking
Treatment at the Institute of Neurological Recovery in Boca Raton, Florida, March 6, 2018, twenty two months after stroke. Immediate improvements in aphasia, apraxia of speech, walking, etc.
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Posted by INR PLLC on Thursday, March 8, 2018 at 5:03 pm
Filed under Blog Posts, Brain Research, INR News, Uncategorized · Tagged with Anti-Inflammatory, antiinflammatory, Boca Raton, Cognition, Dr. Tobinick, Edward Tobinick MD, Etanercept, Florida, Gait, Inflammation, INR, INR PLLC, Institute of Neurological Recovery, Perispinal Etanercept, Post Stroke, PostStroke, PSE, Stroke, Stroke Recovery, Stroke Rehabilitation, Stroke Treatment, TNF, TNFa, Tobinick, Tumor Necrosis Factor Alpha, Walking
Click here to see Part 1.
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Disclaimer: Individual results vary, not all patients respond. Additional doses may be necessary to maintain the clinical response. Treatment is innovative (“off-label”). Terms of Use
Posted by INR PLLC on Friday, January 26, 2018 at 6:28 pm
Filed under Blog Posts, Brain Research, INR News, Uncategorized · Tagged with Anti-Inflammatory, antiinflammatory, Boca Raton, central post-stroke pain, Dance, Dancing, Dr. Tobinick, Edward Tobinick MD, Florida, Inflammation, INR, INR PLLC, Institute of Neurological Recovery, Pain, Papua New Guinea, Perispinal, Perispinal Etanercept, Post Stroke, Post Stroke Pain, PostStroke, PSE, spasticity, Stroke, Stroke Recovery, Stroke Rehabilitation, Stroke Treatment, TNF, TNFa, Tobinick, Tumor Necrosis Factor Alpha
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Disclaimer: Individual results vary, not all patients respond. Additional doses may be necessary to maintain the clinical response. Treatment is innovative (“off-label”). Terms of Use
Posted by INR PLLC on Monday, January 22, 2018 at 4:07 pm
Filed under Blog Posts, Brain Research, INR News, Uncategorized · Tagged with Anti-Inflammatory, antiinflammatory, Boca Raton, central post-stroke pain, Dr. Tobinick, Edward Tobinick MD, Florida, Gait, Inflammation, INR, INR PLLC, Institute of Neurological Recovery, Pain, Perispinal, Perispinal Etanercept, Post Stroke, Post Stroke Pain, PostStroke, PSE, Shoulder Pain, spasticity, Stroke, Stroke Recovery, Stroke Rehabilitation, Stroke Treatment, TNF, TNFa, Tobinick, Tumor Necrosis Factor Alpha, Walking