May 10, 2014 Two scientists from the UCLA Department of Neurology have published a new research article entitled “Intracerebral hemorrhage in mouse models: therapeutic interventions and functional recovery“, Metab Brain Dis. 2014 epub May 10. The authors recognize intracerebral hemorrhage as a subtype of focal stroke and the most common form of brain hemorrhage. The authors explain, “With direct blood extravasation into brain, secondary inflammation is a substantial feature.... Read More
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TNF is an immune signaling molecule. Increasing scientific evidence suggests that excess (pathologic) levels of TNF, if present in the brain, may impair brain function. Physiological levels of TNF are involved in the regulation of normal brain processes, such as the regulation of synaptic function(1-3). In the 1980’s Clark and his colleagues suggested that excess TNF was involved in the pathophysiology of brain dysfunction associated with malaria(4, 5). In 1988, the clinical results of the initial... Read More
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Of great interest, independent scientists from around the world continue to provide scientific evidence in basic science models, in addition to the INR’s published clinical studies, supporting the potential of etanercept to favorably intervene in brain disorders of diverse etiology: 1. Ye, J., R. Jiang, M. Cui, B. Zhu, L. Sun, Y. Wang, A. Zohaib, Q. Dong, X. Ruan, Y. Song, W. He, H. Chen, and S. Cao, Etanercept reduces neuroinflammation and lethality in mouse model of Japanese... Read More
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A new study, published 14 March 2014, provides further evidence of the central role of TNF in stroke pathobiology: “The abstract begins: “Stroke is a major cause of death worldwide and the leading cause of permanent disability. Although reperfusion is currently used as treatment, the restoration of blood flow following ischaemia elicits a profound inflammatory response mediated by proinflammatory cytokines such as tumour necrosis factor (TNF), exacerbating tissue damage and worsening... Read More
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For further information regarding the INR, please see the following sources, accessible by clicking on the links below: Google Scholar citations to the scientific publications of INR physicians The abstract and link to the full text of the published, peer-reviewed article, written by multiple INR physicians, including Nancy Kim MD and Edward Tobinick MD, entitled “Selective TNF Inhibition for chronic stroke and traumatic brain injury: an observational study involving 629 consecutive patients….” The... Read More
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J Neuroinflammation. 2013 Aug 20;10(1):103. doi: 10.1186/1742-2094-10-103. Title: TNF-alpha antagonism improves neurological recovery in murine intracerebral hemorrhage Lei B, Dawson HN, Roulhac-Wilson B, Wang H, Laskowitz DT, James ML. Source: Multidisciplinary Neuroprotection Laboratories, 132 Sands Bldg, Durham, NC 27710, USA. michael.james@duke.edu. Abstract BACKGROUND: Intracerebral hemorrhage (ICH) is a devastating stroke subtype characterized by a prominent neuroinflammatory response.... Read More
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Charlie and Cheryll Giles with Dr. Tobinick at the INR 100 UCLA Medical Plaza July 11, 2013 Three years after the original filming of “A New Shot at Life” by 60 Minutes Australia. To view the documentary, please go to the original 60 Minutes Australia feature, available here. Read More →
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On March 30, 2013, new data from the UCSF Memory and Aging Center published pointing to excess TNF as a potential therapeutic target for certain forms of dementia. In particular, elevated TNF levels were observed in the cohort of individuals examined with semantic variant PPA (primary progressive aphasia) (see Miller ZA, Rankin KP, Graff-Radford NR, Takada LT, Sturm VE, Cleveland CM, Criswell LA, Jaeger PA, Stan T, Heggeli KA, et al: TDP-43 frontotemporal lobar degeneration and autoimmune disease.... Read More
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We were so pleased that Jan returned to visit us on March 11 from Kennett, Missouri with her husband. She is holding the story the Daily Dunklin Democrat had printed on February 17 about her rapid improvement after treatment. To read the whole story please click on the following link to the webpage of the Daily Dunklin Democrat (click here). Read More →
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TNF-alpha receptor antagonist, R-7050, improves neurological outcomes following intracerebral hemorrhage in mice Melanie D. King, Cargill H. Alleyne Jr., Krishnan M. Dhandapani Department of Neurosurgery, Medical College of Georgia, Georgia Regents University, Augusta, GA, USA Abstract Intracerebral hemorrhage (ICH), the most common form of hemorrhagic stroke, exhibits the highest acute mortality and the worst long-term prognosis of all stroke subtypes. Unfortunately, treatment options for... Read More
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