Institute of Neurological Recovery – Stroke

New study provides further evidence of the central role of TNF in stroke pathophysiology

A new study, published 14 March 2014, provides further evidence of the central role of TNF in stroke pathobiology: “The abstract begins: “Stroke is a major cause of death worldwide and the leading cause of permanent disability. Although reperfusion is currently used as treatment, the restoration of blood flow following ischaemia elicits a profound inflammatory response mediated by proinflammatory cytokines such as tumour necrosis factor (TNF), exacerbating tissue damage and worsening... Read More

INR News and Links

For further information regarding the INR, please see the following sources, accessible by clicking on the links below: Google Scholar citations to the scientific publications of INR physicians The abstract and link to the full text of the published, peer-reviewed article, written by multiple INR physicians, including Nancy Kim MD and Edward Tobinick MD, entitled “Selective TNF Inhibition for chronic stroke and traumatic brain injury: an observational study involving 629 consecutive patients….” The... Read More

“… a compelling therapeutic strategy to improve neurological outcome in patients after ICH”

J Neuroinflammation. 2013 Aug 20;10(1):103. doi: 10.1186/1742-2094-10-103. Title: TNF-alpha antagonism improves neurological recovery in murine intracerebral hemorrhage Lei B, Dawson HN, Roulhac-Wilson B, Wang H, Laskowitz DT, James ML. Source: Multidisciplinary Neuroprotection Laboratories, 132 Sands Bldg, Durham, NC 27710, USA. michael.james@duke.edu. Abstract BACKGROUND: Intracerebral hemorrhage (ICH) is a devastating stroke subtype characterized by a prominent neuroinflammatory response.... Read More

Charlie and Cheryll at the INR Los Angeles July 2013

Charlie and Cheryll Giles with Dr. Tobinick at the INR 100 UCLA Medical Plaza July 11, 2013 Three years after the original filming of “A New Shot at Life” by 60 Minutes Australia. To view the documentary, please go to the original 60 Minutes Australia feature, available here.  Read More →

New data points to excess TNF as a potential therapeutic target for certain forms of dementia

On March 30, 2013, new data from the UCSF Memory and Aging Center published pointing to excess TNF as a potential therapeutic target for certain forms of dementia. In particular, elevated TNF levels were observed in the cohort of individuals examined with semantic variant PPA (primary progressive aphasia) (see Miller ZA, Rankin KP, Graff-Radford NR, Takada LT, Sturm VE, Cleveland CM, Criswell LA, Jaeger PA, Stan T, Heggeli KA, et al: TDP-43 frontotemporal lobar degeneration and autoimmune disease.... Read More

Jan Sanders returns to Boca Raton from Kennett, Missouri on March 11, 2013

We were so pleased that Jan returned to visit us on March 11 from Kennett, Missouri with her husband. She is holding the story the Daily Dunklin Democrat had printed on February 17 about her rapid improvement after treatment.  To read the whole story please click on the following link to the webpage of the Daily Dunklin Democrat (click here).  Read More →

Basic Science News: TNF inhibition reduces neurovascular injury after Intracerebral Hemorrhage

TNF-alpha receptor antagonist, R-7050, improves neurological outcomes following intracerebral hemorrhage in mice Melanie D. King, Cargill H. Alleyne Jr., Krishnan M. Dhandapani Department of Neurosurgery, Medical College of Georgia, Georgia Regents University, Augusta, GA, USA Abstract Intracerebral hemorrhage (ICH), the most common form of hemorrhagic stroke, exhibits the highest acute mortality and the worst long-term prognosis of all stroke subtypes. Unfortunately, treatment options for... Read More

February 4, 2013 article in Massachusetts newspaper discusses new stroke treatment

February 4, 2012 article in The Recorder, Greenfield, Massachusetts: http://www.recorder.com/home/4088414-95/krug-treatment-stroke-able New treatment gives stroke victim hope Recorder/Paul Franz Rodney Krug, 91, of Bernardston at the Bernardston Senior Center. By DAVID RAINVILLE Recorder Staff Sunday, February 3, 2013 (Published in print: Monday, February 4, 2013) For the full article, please go to:http://www.recorder.com/home/4088414-95/krug-treatment-stroke-able  Read More →

Science News: New pathology study: Inflammation persists for years after a single traumatic brain injury

Brain. 2013 Jan;136(Pt 1):28-42. doi: 10.1093/brain/aws322. Inflammation and white matter degeneration persist for years after a single traumatic brain injury. Johnson VE, Stewart JE, Begbie FD, Trojanowski JQ, Smith DH, Stewart W. Source Penn Centre for Brain Injury and Repair and Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. Abstract A single traumatic brain injury is associated with an increased risk of dementia and,... Read More

On October 26, 2012, the peer-reviewed INR scientific article, detailing nearly two years of clinical results utilizing the patented new off-label treatment developed at the INR for chronic neurological impairment following stroke or traumatic brain injury, published. The full-text of the article is available at this link: http://www.ncbi.nlm.nih.gov/pubmed/23100196 . CNS Drugs. 2012 Oct 26. [Epub ahead of print] Selective TNF Inhibition for Chronic Stroke and Traumatic Brain Injury : An Observational... Read More