May 2, 2016 (Los Angeles, Boca Raton): On April 27, 2016, the peer-reviewed review article entitled, Perispinal Delivery of CNS Drugs, by Edward Tobinick MD, published online in the scientific journal CNS Drugs. The abstract of the article states: Perispinal injection is a novel emerging method of drug delivery to the central nervous system (CNS). Physiological barriers prevent macromolecules from efficiently penetrating into the CNS after systemic administration. Perispinal injection is designed... Read More
Comments: 0
“The New Stroke Treatment That’s Changing Lives” Sunday Night (Australia), March 29, 2015 On March 29, 2015 the television news program “Sunday Night” in Australia aired a national news feature story about INR’s perispinal etanercept stroke treatment. The story was entitled “The New Stroke Treatment That’s Changing Lives”, and it is accessible online at the link: https://au.news.yahoo.com/sunday-night/features/a/26856981/the-new-stroke-treatment-thats-changing-lives/ Sunday... Read More
Comments: 0
July 2015: Two Australian scientists, including an Emeritus Professor at the Australian National University and a neuroscientist from the Garvan Institute, have published a new review article for neurologists on TNF. The article discusses the science of TNF, its physiology and the scientific rationale for perispinal etanercept for treatment of post-stroke neurological dysfunction and other brain disorders. The article is open access, so the INR PLLC has made it freely downloadable by double-clicking... Read More
Comments: 0
Patient from Somalia, with her son and Dr. Tobinick, at the INR Boca Raton, June 1, 2015, minutes after treatment. Read More →
Comments: 0
Rapid neurological recovery beginning within minutes, 1.5 years after stroke in a patient from New Zealand. The patient’s wife describes improvement in walking ability, language abilities, sensation, vision, hearing, taste, etc. Video made at the Institute of Neurological Recovery in Los Angeles on June 9, 2014. Treatment with a single dose was on June 2, 2014. 6 July 2014 Dave and Brenda’s story published in the Otago Daily Times: “Rising to the challenge of a stroke” by... Read More
Comments: 0
May 10, 2014 Two scientists from the UCLA Department of Neurology have published a new research article entitled “Intracerebral hemorrhage in mouse models: therapeutic interventions and functional recovery“, Metab Brain Dis. 2014 epub May 10. The authors recognize intracerebral hemorrhage as a subtype of focal stroke and the most common form of brain hemorrhage. The authors explain, “With direct blood extravasation into brain, secondary inflammation is a substantial feature.... Read More
Comments: 0
TNF is an immune signaling molecule. Increasing scientific evidence suggests that excess (pathologic) levels of TNF, if present in the brain, may impair brain function. Physiological levels of TNF are involved in the regulation of normal brain processes, such as the regulation of synaptic function(1-3). In the 1980’s Clark and his colleagues suggested that excess TNF was involved in the pathophysiology of brain dysfunction associated with malaria(4, 5). In 1988, the clinical results of the initial... Read More
Comments: 0
Of great interest, independent scientists from around the world continue to provide scientific evidence in basic science models, in addition to the INR’s published clinical studies, supporting the potential of etanercept to favorably intervene in brain disorders of diverse etiology: 1. Ye, J., R. Jiang, M. Cui, B. Zhu, L. Sun, Y. Wang, A. Zohaib, Q. Dong, X. Ruan, Y. Song, W. He, H. Chen, and S. Cao, Etanercept reduces neuroinflammation and lethality in mouse model of Japanese... Read More
Comments: 0
A new study, published 14 March 2014, provides further evidence of the central role of TNF in stroke pathobiology: “The abstract begins: “Stroke is a major cause of death worldwide and the leading cause of permanent disability. Although reperfusion is currently used as treatment, the restoration of blood flow following ischaemia elicits a profound inflammatory response mediated by proinflammatory cytokines such as tumour necrosis factor (TNF), exacerbating tissue damage and worsening... Read More
Comments: 0
For further information regarding the INR, please see the following sources, accessible by clicking on the links below: Google Scholar citations to the scientific publications of INR physicians The abstract and link to the full text of the published, peer-reviewed article, written by multiple INR physicians, including Nancy Kim MD and Edward Tobinick MD, entitled “Selective TNF Inhibition for chronic stroke and traumatic brain injury: an observational study involving 629 consecutive patients….” The... Read More
Comments: 0